This course teaches fundamental knowledge about protein structures, protein interactions and protein folding. It will discuss in detail the most common methods on how proteins and macromolecular complexes are studied, such as X-ray crystallography, NMR-spectroscopy, and electron microscopy. The course will offer about 50 percent direct teaching, 40 percent discussion of papers in a journal club style, and 10 percent hands-on practicals on software packages relevant to structural biology. Prereqs., MCDB 3120 and 3500 or MCDB 3135 and 3145.